A person you are caring for has a known GI bleed. What drug is contraindicated?

The drug that is contraindicated in a person with a known gastrointestinal (GI) bleed is Enoxaparin (Lovenox). Enoxaparin is a low molecular weight heparin used primarily for the prevention and treatment of thromboembolic disorders. While it is effective in preventing clots, its anticoagulant properties can exacerbate bleeding risks, particularly in individuals with existing bleeding conditions such as a GI bleed.

Administering Enoxaparin in this context could lead to further complications, including increased blood loss and difficulty in managing the current bleed. In patients with a known history of bleeding, careful consideration of anticoagulant therapy is essential to avoid worsening their condition.

Other medications listed, while they also have implications for bleeding risk, may not be as strictly contraindicated in the same way Enoxaparin is. Aspirin and ibuprofen, both nonsteroidal anti-inflammatory drugs (NSAIDs), can affect platelet function and gastric mucosal integrity but are not specifically contraindicated without considering the individual patient's entire clinical scenario. Metformin, primarily used in the management of diabetes, does not have a direct impact on bleeding risk and is not contraindicated in patients with a GI bleed when considering its mechanism and effects.