What primarily causes "Red Man" Syndrome during vancomycin administration?

"Red Man" Syndrome is primarily associated with the administration of vancomycin, and it is primarily caused by an increase in histamine production. This particular reaction is not due to an allergic response but rather a direct effect of the medication on the body. When vancomycin is infused too quickly, it can lead to the rapid release of histamine from mast cells, causing symptoms such as flushing, rash, and hypotension.

Histamine is a compound involved in inflammatory responses, and its release is what leads to the characteristic redness and sometimes itching associated with "Red Man" Syndrome. This phenomenon highlights the importance of proper infusion rates when administering vancomycin. A slow infusion may help mitigate these effects, but the underlying cause is primarily linked to histamine release rather than the infusion rate itself being too slow or a direct allergic reaction to the drug.