What side effect might occur with rapid infusion of vancomycin?

The correct choice highlights that rapid infusion of vancomycin can lead to red man syndrome, which is characterized by flushing, rash, pruritus (itching), and sometimes hypotension. This syndrome results from the release of histamine due to a quick increase in drug levels, which sensitizes the mast cells and basophils. The rapid infusion does not allow the body to tolerate the drug's effects, precipitating this reaction.

This specific side effect is significant for healthcare providers to recognize and manage appropriately. It underscores the importance of administering vancomycin at a slower rate to mitigate the risk of red man syndrome and ensure patient safety during treatment. Other options such as headache, fever, and nausea may occur with various medications but are not directly related to the rapid infusion of vancomycin.