Which type of medication is contraindicated in patients receiving anticoagulation therapy?

Non-steroidal anti-inflammatory drugs (NSAIDs) are contraindicated in patients receiving anticoagulation therapy because they can increase the risk of bleeding complications. NSAIDs, such as ibuprofen and naproxen, inhibit platelet function and can cause gastrointestinal irritation and ulceration, which may lead to bleeding. When anticoagulants are used concurrently, this additive effect on bleeding risk can significantly raise the chances of serious hemorrhagic events.

In contrast, antibiotics, antihistamines, and antidepressants generally do not have the same level of risk associated with bleeding and are often considered safer options for patients on anticoagulation therapy. While caution is still warranted with any medication in these patients, NSAIDs pose a specific risk of exacerbating bleeding issues that necessitates their avoidance.